Dexedrine contains the active ingredient d-amphetamine, while Adderall contains a 3:1 mixture of immediate-release d-amphetamine and l-amphetamine. Extended-release formulas of Adderall, such as Adderall XR, generally contain equal measures of immediate-release and delayed-release d-amphetamine and l-amphetamine.
Dexedrine is also available in a sustained-release formula (Dexedrine Spansule), containing time-release d-amphetamine.
Currently, immediate-release types of Dexedrine and Adderall are both approved by the U.S. Food and Drug Administration (FDA) for the treatment of ADHD in children aged 3 and older.
The extended-release types Dexedrine Spansule and Adderall XR are not approved for use in children under the age of 6. Dexedrine Spansule is also not approved for use in individuals over the age of 16.
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