Dexedrine contains the active ingredient d-amphetamine, while Adderall contains a 3:1 mixture of immediate-release d-amphetamine and l-amphetamine. Extended-release formulas of Adderall, such as Adderall XR, generally contain equal measures of immediate-release and delayed-release d-amphetamine and l-amphetamine.

Dexedrine is also available in a sustained-release formula (Dexedrine Spansule), containing time-release d-amphetamine.

Currently, immediate-release types of Dexedrine and Adderall are both approved by the U.S. Food and Drug Administration (FDA) for the treatment of ADHD in children aged 3 and older.

The extended-release types Dexedrine Spansule and Adderall XR are not approved for use in children under the age of 6. Dexedrine Spansule is also not approved for use in individuals over the age of 16.

Minimum order 100 tabs

Buy Dexedrine Online

Indications

DEXEDRINE is indicated in:
Narcolepsy
Attention Deficit Disorder with Hyperactivity: As an integral part of a total treatment
program that typically includes other remedial measures (psychological, educational, social) for
a stabilizing effect in pediatric patients (ages 3 years to 16 years) with a behavioral syndrome
characterized by the following group of developmentally inappropriate symptoms: Moderate to
severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. The
diagnosis of this syndrome should not be made with finality when these symptoms are only of
comparatively recent origin. Nonlocalizing (soft) neurological signs, learning disability, and
abnormal EEG may or may not be present, and a diagnosis of central nervous system dysfunction
may or may not be warranted.

Buy Dexedrine Online

How To Take

The doctor may adjust the amount of drug taken by you
or your child until it is right for you or your child. From time to
time, the doctor may interrupt treatment to check you or your
child’s symptoms while you or your child are not taking the drug.
Your doctor may do regular checks of the blood, heart, and blood
pressure while taking DEXEDRINE®. Children should have their
height and weight checked often while taking DEXEDRINE®.
DEXEDRINE® treatment may be stopped if a problem is found
during these check-ups.

Buy Dexedrine Online

Side Effects

Cardiovascular: Palpitations, tachycardia, elevation of blood pressure. There have been
isolated reports of cardiomyopathy associated with chronic amphetamine use.
Central Nervous System: Psychotic episodes at recommended doses (rare), overstimulation,
restlessness, dizziness, insomnia, euphoria, dyskinesia, dysphoria, tremor, headache,
exacerbation of motor and phonic tics, and Tourette’s syndrome.
Gastrointestinal: Dryness of the mouth, unpleasant taste, diarrhea, constipation, other
gastrointestinal disturbances. Anorexia and weight loss may occur as undesirable effects.
Allergic: Urticaria.
Endocrine: Impotence, changes in libido.
Other serious side effects include:

• Slowing of growth (height and weight) in children
• Seizures, mainly in patients with a history of seizures
• Eyesight changes or blurred vision
Common side effects include:
• Fast heart beat
• Decreased appetite
• Tremors
• Headache
• Trouble sleeping
• Dizziness
• Stomach upset
• Weight loss
• Dry mouth
DEXEDRINE may affect your or your child’s ability to drive or do other dangerous activities.
Talk to your doctor if you or your child has side effects that are bothersome or do not go away.

Buy Dexedrine Online

Contraindications

DEXEDRINE (dextroamphetamine sulfate) is contraindicated in patients with:
• Advanced arteriosclerosis
• Symptomatic cardiovascular disease
• Moderate to severe hypertension
• Hyperthyroidism
• Hypersensitivity or idiosyncrasy to sympathomimetic amines
• Agitated state
• History of drug abuse
• Glaucoma
• Anxiety
• Tension
• Hypersensitivity to DEXEDRINE or to any ingredient in the formulation or component of
the container. For complete listing, see the Dosage Forms, Composition and Packaging
section of the product monograph.
• Motor tics or with a family history of diagnosis of Tourette’s Syndrome (verbal tics).
• Concomitant treatment with MAO inhibitors or within 14 days following the withdrawal of
MAO inhibitors.

Dexmethylphenidate hydrochloride is methyl α-phenyl-2-piperidine acetate hydrochloride, (R,R’)-(+)-. Its empirical formula is C14H19NO2&bul;HCl. Its molecular weight is 269.77 and its structural formula is:

FOCALIN XR (dexmethylphenidate hydrochloride) Structural Formula Illustration

Dexmethylphenidate hydrochloride is a white to off white powder. Its solutions are acid to litmus. It is freely soluble in water and in methanol, soluble in alcohol, and slightly soluble in chloroform and in acetone.

Inactive ingredients: ammonio methacrylate copolymer, FD&C Blue #2 (5 mg, 15 mg, 25 mg, 35 mg, and 40 mg strengths), FDA/E172 yellow iron oxide (10 mg, 15 mg, 30 mg, 35 mg, and 40 mg strengths), gelatin, ink Tan SW-8010, methacrylic acid copolymer, polyethylene glycol, sugar spheres, talc, titanium dioxide, and triethyl citrate.

Buy Focalin XR Online

USES

This medication is used to treat attention deficit hyperactivity disorder – ADHD. It works by changing the amounts of certain natural substances in the brain. Dexmethylphenidate belongs to a class of drugs known as stimulants. It can help increase your ability to pay attention, stay focused on an activity, and control behavior problems. It may also help you to organize your tasks and improve listening skills.

How to use Focalin XR

Read the Medication Guide provided by your pharmacist before you start taking dexmethylphenidate and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once daily in the morning, with or without food. Taking this medication late in the day may cause trouble sleeping (insomnia).

The dosage is based on your medical condition and response to treatment. Your doctor may direct you to gradually increase or decrease your dose. Also, if you have used it for a long time, do not suddenly stop using this drug without consulting your doctor.

Do not break, crush, or chew this medication. Doing so can release all of the drug at once, increasing the risk of side effects. Swallow the capsules whole. If you have trouble swallowing the capsule, you may open the capsule and carefully sprinkle its contents on a spoonful of cool applesauce. Swallow all of the mixture right away without chewing it. Then drink a glass of cool liquid to make sure you have swallowed all of the dose. Do not prepare the mixture ahead of time.

Methylphenidate and dexmethylphenidate are different medications and do not provide the same amount of medicine. Do not switch between products unless your doctor tells you to.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as depression, suicidal thoughts, or other mental/mood changes) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.

When this medication is used for a long time, it may not work as well. Talk to your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

Buy Focalin XR Online

Tell your doctor if your condition does not improve or if it worsens.

DRUG INTERACTIONS

Focalin XR should not be used in patients being treated (currently or within the preceding 2 weeks) with MAO Inhibitors

Because of possible effects on blood pressure, Focalin XR should be used cautiously with pressor agents.

Methylphenidate may decrease the effectiveness of drugs used to treat hypertension.

Dexmethylphenidate is metabolized primarily to d-ritualistic acid by de-esterification and not through oxidative pathways.

The effects of gastrointestinal pH alterations on the absorption of dexmethylphenidate from Focalin XR have not been studied. Since the modified release characteristics of Focalin XR are pH dependent, the coadministration of antacids or acid suppressants could alter the release of dexmethylphenidate.

Human pharmacologic studies have shown that racemic methylphenidate may inhibit the metabolism of coumarin anticoagulants, anticonvulsants (e.g., phenobarbital, phenytoin, primidone), and tricyclic drugs (e.g., imipramine, clomipramine, desipramine). Downward dose adjustments of these drugs may be required when given concomitantly with methylphenidate. It may be necessary to adjust the dosage and monitor plasma drug concentration (or, in the case of coumarin, coagulation times), when initiating or discontinuing methylphenidate.

Drug Abuse And Dependence

Focalin XR, like other methylphenidate products, is classified as a Schedule II controlled substance by Federal regulation. Abuse, Dependence, Tolerance

DOSAGE AND ADMINISTRATION

Focalin XR is for oral administration once daily in the morning.

Focalin XR may be swallowed as whole capsules or alternatively may be administered by sprinkling the capsule contents on a small amount of applesauce

. Focalin XR capsules and/or their contents should not be crushed, chewed, or divided.

The capsules may be carefully opened and the beads sprinkled over a spoonful of applesauce. The mixture of drug and applesauce should be consumed immediately in its entirety. The drug and applesauce mixture should not be stored for future use.

Dosage should be individualized according to the needs and responses of the patient.

Patients New To Methylphenidate

The recommended starting dose of Focalin XR for patients who are not currently taking dexmethylphenidate or racemic methylphenidate, or for patients who are on stimulants other than methylphenidate, is 5 mg/day for pediatric patients and 10 mg/day for adult patients.

Dosage may be adjusted in 5 mg increments for pediatric patients and in 10 mg increments for adult patients. In general, dosage adjustments may proceed at approximately weekly intervals. The patient should be observed for a sufficient duration at a given dose to ensure that a maximal benefit has been achieved before a dose increase is considered. In dose-response (fixed-dose) studies (pediatric from 10 to 30 mg/day and adult from 20 to 40 mg/day), all doses were effective vs. placebo. There was no clear finding, however, of greater average benefits for the higher doses compared to the lower doses. Adverse events and discontinuations, however, were dose-related. Doses above 30 mg/day in pediatrics and 40 mg/day in adults have not been studied and are not recommended.

Patients Currently Using Methylphenidate

For patients currently using methylphenidate, the recommended starting dose of Focalin XR is half the total daily dose of racemic methylphenidate. Patients currently using Focalin (dexmethylphenidate) may be switched to the same daily dose of Focalin XR.

Maintenance/Extended Treatment

There is no body of evidence available from controlled trials to indicate how long the patient with ADHD should be treated with Focalin XR. It is generally agreed, however, that pharmacological treatment of ADHD may be needed for extended periods. Nevertheless, the physician who elects to use Focalin XR for extended periods in patients with ADHD should periodically reevaluate the long-term usefulness of the drug for the individual patient with periods off medication to assess the patient’s functioning without pharmacotherapy. Improvement may be sustained when the drug is either temporarily or permanently discontinued.

Quillivant, like other methylphenidate medications (Ritalin, Concerta), is prescribed to individuals diagnosed with ADHD. As a liquid, it provides an alternative for people unable to swallow pills.

Quillivant is only recommended for individuals over six years of age, and the effects of long-term use of Quillivant are not currently known. This medication is not suggested for people with cardiovascular issues (including structural abnormalities), high blood pressure, psychosis, or active manic episodes.

Quillivant was first available in 2012, and is the only liquid medication used to treat ADHD.

How Does Quillivant Work?

Because Quillivant is extended release, it lasts twice as long as many ADHD medications. It is a central nervous system (CNS) stimulant and activates certain areas of the brain to increase attention, focus, and concentration skills. It also works to reduce hyperactivity, by increasing impulse control.

It is important to take Quillivant exactly as prescribed, to decrease the potential of abuse. Quillivant should be taken in the morning, due to its slow-release factors, otherwise it can result in insomnia.

Other common side effects of Quillivant are similar to other methylphenidate medications, and include decreased appetite, nausea, restlessness, mild anxiety, dry mouth, and weight loss.

When beginning Quillivant, it is important to maintain the supervision of the prescribing doctor. The recommended starting dose is 20 mg each day, in the morning. However, the lowest effective dose is different person to person, and doctors will adjust accordingly.